Journal article

Epigenetic markers of ageing and cancer risk

DL Li, J Ryan, AM Hodge, MC Southey, GG Giles, RL Milne, PA Dugué

Ageing Research Reviews | Published : 2026

DOI: 10.1016/j.arr.2026.103041

Abstract

Epigenetic alterations are an important shared hallmark of ageing and cancer. The development of epigenetic markers of ageing using blood DNA methylation data has been an active area of research. These markers have been used to assess disease risk, with potential to shed light on the complex link between ageing and cancer. We comprehensively summarised the literature on the most widely used and recently developed epigenetic markers of ageing, and synthesised the findings from studies that assessed their associations with cancer risk. Using data from eight cancer case-control studies (Ncases = 3624) nested in the Melbourne Collaborative Cohort Study, we assessed and compared associations of t..

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Keywords

2.1 Biological and Endogenous Factors
31 Biological Sciences
Breast Cancer
Cancer Genomics
Women'S Health
32 Biomedical and Clinical Sciences
Human Genome
Epigenetic Age
Digestive Diseases
Urologic Diseases
3105 Genetics
Genetics
Cancer Risk
3211 Oncology and Carcinogenesis
Cancer
Ageing
Lung Cancer
Lung
Colo-Rectal Cancer
Biological Ageing
Prevention